Withaferin A Suppresses Liver Tumor Growth in a Nude Mouse. Purpose: To investigate the effect of withaferin A on tumor growth and metastasis in liver in a nude mouse model. Methods: Withaferin A was injected through a portal vein to the orthotopic liver tumor in a nude mice model. Wang Hui Li Tianran Tian Jiahe Qu Baolin Zhu Hui International Nuclear Information System (INIS) The effect of .Īnti-EGFR therapy radiosensitizes human lung adenocarcinoma xenograft in nude mouse Xenogen in vivo imaging system was used to monitor tumor growth and metastasis. ![]() Objective: To investigate the effect of Gefitinib on radiosensitivity of human lung adenocarcinoma xenograft in nude mouse. Methods: Human lung adenocarcinoma cell line A549 was used to establish nude mouse xenograft tumor model. The mice were derided into 4 groups: control, irradiation alone, Gefinitib alone and radiation combined with Genifitib. Gefitinib was daily administered by gavage at 100 mg/(kg Radiation schedule was 3 fractions of 5 Gy, once daily. In the combination group, radiotherapy was performed 2 hours after Gefitinib administration. Tumor diameter was measured every other day. The Charles River " hairless" rat mutation is distinct from the hairless mouse alleles.Percentage of tumor growth inhibition, growth delay time and regrowth delay time were evaluated. The Charles River (CR) " hairless" rat is one of the autosomal recessive hypotrichotic animal models actively studied in pharmacologic and dermatologic research. Despite its widespread use, the molecular basis of this monogenic mutation remains unknown, and the skin histologic features of this phenotype have never been described. However, the designation " hairless" has been used as an extension of the hairless mouse (hr) nomenclature on the basis of the clinical absence of hairs in both phenotypes. Uploaded by SkylineFm on Up votes: 5 Down votes: 0 Set as preferred image. See Sandra Orlow pictures, photo shoots, and listen online to the latest music. We present a description of the histopathologic changes in heterozygous and homozygous CR hairless rat mutants during the first month of life. See Sandra Orlow pictures, photo shoots, and listen online to the latest music. The postnatal homozygous rat skin was characterized by abnormal keratinization of the hair shaft and formation of a thick and dense layer of corneocytes in the lower portion of the epidermal stratum corneum. This layer prevented the improperly keratinized hair shaft from penetrating the skin surface. Starting from the latest stages of hair follicle (HF) development, obvious signs of HF degeneration were observed in homozygous skin. The film had numerous nude scenes and Brooke had to testify that they used a body double, as she was only 14 years old at that time. In the same year, she also played in the movie The Blue Lagoon. This process was extremely rapid, and by day 12, mainly atrophic HFs with abnormal or broken hairs were present in the skin. She appeared in this Calvin Klein ad at the age of 15. Therefore, the mutation in the CR rat abrogates cell proliferation in the hair matrix and affects keratinocyte differentiation in the HF and interfollicular epidermis, a phenotype that is completely distinct from hr/hr. ![]() To test whether the CR rat harbored a mutation in the hr gene, we analyzed the coding region of this gene and consensus intron splice site sequences in mutant rats and found no mutation, further supporting phenotypic evidence that the hairless phenotype in CR rats is not allelic with hairless.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |